¬üFDA­º­ã¦åÀù°ò¦]Àøªk
ªvÀù¯g¶i·s®É¥N ¤K¦¨±wªÌ¦³®Ä

[2017.08.31] µoªí
¤kµ£Ãh¯S¶Â¼w5¦~«e±µ¨ü³oºØ¹êÅç©ÊÀøªk¡A¥Õ¦å¯f¤wªø´Á½w¸Ñ¡C¡]¬üÁpªÀ¡^
¿ÕµØ¤½¥q¬ãµoªºÃĪ«Kymriah¡C¡]¬üÁpªÀ¡^

¡iºî¦X³ø¹D¡j¬ü°ê­¹«~¤ÎÃĪ«ºÞ²z§½(FDA)¡A©P¤T(30¤é)§å­ã¥þ°ê­ººØ°ò¦]Àøªk¡A¯A¤Î¨Ï¥Î±wªÌ¥»¨­ªº§K¬Ì²Ó­M¨Ó¹ï§Ü¥Õ¦å¯f¡A¬°ªvÀøÀù¯g¶}©Ý·s®É¥N¡C

³oÀøªk¥Ñ¿ÕµØ¤½¥q(Novartis)¬ãµo¡A¨ä²£«~ºÙ¬°Kymriah (tisagenlecleucel)¡C³oºØ¦W¬°CAR-T²Ó­MÀøªkªºªº§K¬ÌªvÀø¡A¦Ü¤µ³QºÙ§@CTL019¡C¬ü°êFDA§å­ã³oºØÀøªk¡A¥i¥H¨Ï¥Î©ó25·³©Î¥H¤U±w¦³«æ©Ê²O¤Ú²y¥Õ¦å¯f(ALL)ªº¨àµ£©M«C¦~¡C

FDA¦bÁn©ú¤¤ªí¥Ü¡A³o¦¸§å®Ö¬O¤@¦¸¾ú¥v©Ê¦æ°Ê¡A±N¤Þ¶i·sªºªvÀø¤èªk¹ï¥IÀù¯g©M¨ä¥LÄY­«©M¦M¤Î¥Í©Rªº¯e¯f¡C

¬ã¨sÅã¥Ü¡A83%±wªÌ¹ï³oÀøªk¦³¤ÏÀ³¡A¨Ã¦b3­Ó¤ë¤º¹F­P½w¸Ñ¡C³oÀøªk¨Ã«DÃĪ«©Î¤@ºØ¤ÆÀø¡A¥¦¨Ï¥Î±wªÌ¥»¨­ºÙ¬°T²Ó­Mªº§K¬Ì²Ó­M¡A¥H¤Î¥Õ¦å²Ó­M¡C³o¨Ç²Ó­M¥Ñ¯f¤HÅ餺©â¨ú¡A°e¥æ¹êÅç«Ç¡A¥[¤W¯f¬r¸üÅé½s½X«á¡A¦A­«·s½sµ{¡AµM«á¿é°e¦^¯f¤HÅ餺¡A¥Ñ¸g§ï³yªº§K¬Ì²Ó­M§ðÀ»¥Õ¦å¯f¡C

¤£¹L¡A³oºØÀøªk¤]·|¤Þ°_ÄY­«°Æ§@¥Î¡C¯f¤H¸g±`¥X²{¤@ºØºÙ¬°¡u²Ó­M¦]¤lÄÀ©ñ¯g­Ô¸s¡vªº§K¬Ì¾÷¯à¹L±Ó¤ÏÀ³¡A¥i¯à¤Þµo°ª¿N¡B¦åÀ£¼@­°¡A¬Æ¦Ü·l®`¾¹©x¡A»Ý­n¯S§OÀøÅ@¥H±±¨î³o¨Ç¯gª¬¡A¦Ó¤S¤£ªý¼¸§ðÀ»Àù²Ó­Mªº¶i®i¡C

¶O«°¨àµ£Âå°|¤»¦~«e²v¥ý¥ÎCAR-TÀøªkªvÀø¤@¦W¤k«Ä¡A¨Ï¦o±q««¦ºÃä½tÂ\²æÀù¯gªÈÄñ¡A¦Ü¤µ¤´°·±d¦s¬¡¡C

³oºØÀøªk¥²¶·¬°¨C¤@­Ó¯f¤H¤À§O¶i¦æ°ò¦]¤uµ{³B²z¡AªvÀø¶O¥Î47.5¸U¬ü¤¸¡C¤£¹L¡A¿ÕµØ«Å¥¬¦pªG¯f¤H¦b¤@­Ó¤ë¤º¨S¦³¤ÏÀ³¡A±N¤£¦¬¶O¡C

¬Û§Î¤§¤U¡A¥Ø«eªvÀø¦åÀù±`¥Îªº°©Åè²¾´Ó¡A²Ä¤@¦~ªá¶O54¸U¦Ü80¸U¬ü¤¸¡C

Àù²Ó­M¸g±`¯à°÷°kÁר­Åé§K¬Ì¾÷¯à¥Î¥H¹ï¥I¯e¯fªºT²Ó­M¡A¦ÓCAR-TÀøªkÂǵۥ[±jT²Ó­M¨ÏÀù²Ó­MµL©Ò¹P§Î¡C

¬ã¨s¤H­û±q¯f¤H¦å²G¹LÂo¥XT²Ó­M¶i¦æ°ò¦]³B²z¡A¨Ï¨ä¾Ö¦³±MªùÂê©wÀù²Ó­Mªº´O¦X§Ü­ì¨üÅé(chimeric antigen receptor¡ACAR)¡A¦A§â¤Àµõ½Æ»s¦¨´X»õ­Óªº±j¤ÆT²Ó­Mª`®g¦^¯f¤HÅ餺¡A¨Ï¨äÄ~Äò½Æ»s©M¹ï§Ü¯e¯f´X­Ó¤ë©Î´X¦~¡C

CAR-TÀøªk²v¥ýÀò­ã¥Î©óªvÀø¨àµ£«æ©Ê²O¤Ú©Ê¥Õ¦å¯f(ALL)¡F°Ñ¥[¸ÕÅ窺63¦WÄY­«¯f±w¡A¦³83%¦b¤T­Ó¤ë¤º¯f±¡Àò±o½w¸Ñ¡A¤ñ²v»·°ª©ó¨ä¥LÀøªk¡A¦Ó¥B¬ã¨s¤H­û¹ï¦³¨Ç¤H´N¦¹§¹¥þªv¡Ãh©ê§Æ±æ¡C¬ü°ê¨C¦~¦³3000¦h¤H¿©±wALL¡C·sÀøªkªì´Á¥u¦b¤H­û¸g¹L¯S§O°V½mªº20´X­ÓÂåÀø¤¤¤ß´£¨Ñ¡A¯f¤Hªº§K¬Ì²Ó­M±N§N­á°e¨ì·s¿A¦è¦{ªº¿ÕµØ¤u¼t³B²z¡A¾ã­Óµ{§Ç¬ù»Ý¤T­Ó¬P´Á¡C¥Ø«e¥u¦³¦~¬ö¤£¶W¹L25·³ªºALL´_µo¯f¤H¤~¯à±µ¨ü³oºØªvÀø¡A¦Ó¬ü°ê¬ù¦³600­Ó¯f¤H¦X¥G±ø¥ó¡C

°ê®aÀù¯g¬ã¨s©Òµo®i¥X¨ÓªºÃþ¦üCAR-TÀøªk¡A¤µ¦~µy«á¥i±æÀò­ã¥Î¥HªvÀø´c©Ê²O¤ÚÀù¡A¨ä¥L¤½¥q¤]¦bµo®i¹ï¥I¦hµo©Ê°©Åè½Fµ¥¨ä¥L¦åÀùªºÃþ¦üÀøªk¡C

¬ì¾Ç¬É¤]¦bµo®iCAR-TÀøªk¤U¤@­Ó§ó§xÃøªº¥Ø¼Ð¡G¹ï¥I¸£Àù¡B¨ÅÀù¡B¯ØŦÀùµ¥§ó±`¨£ªº©TºAÀù½F¡C

§ó¦h°ê»Ú­n»D
¬P¿w©w¿ï°¨¨Ó¸ÇÁ`²Î ±È¡u²V¦å¡vª§Ä³
·s¥[©YÁ`²Î¿ïÁ|9¤ëÁ|¦æ¡A¤µ¦¸±N«ö¥h¦~­×¾Ë³W©w¡A¾ú¨Ó­º¦¸±Ò°Ê¡u«O¯d¿ïÁ|¡v¾÷¨î¡A¤º©w¥u­­°¨¨Ó¸Ç°Ñ¿ï¡A·N¨ýþÓ¬P¬w±N¥X²{¦Û«Ø°ê­º¥ôÁ`²Î¤×¯Á¤Ò¥ìÂÄ¥H¨Ó... ¸Ô±¡
4¤j±Ú¤À¡uCMIO¡v
·s¥[©Y¦³©Ò¿×¡uCMIO¡vªººØ±Ú¤ÀÃþ¨t²Î¡A§YµØ¸Ç¡]Chinese¡^¡B°¨¨Ó¸Ç¡]Malay¡^¡B¦L«×¸Ç¡]Indian¡^©M¨ä¥LºØ±Ú¡]Others¡^¡]µù... ¸Ô±¡
¯A¦PÃþ½èºÃ °¨«¢¸¦º¸¾D½Â±b
¦b·s¥[©Y±È°_¡u°¨¨Ó¯S½è¡vÁֽת§Ä³¤§»Ú¡A¾F°ê°¨¨Ó¦è¨ÈªºÃþ¦ü­·ªi§ó¤W¤É¦Ü¬FªvªZ¾¹ªºµ{«×¡X¡X´¿¥wúù¤j°¨¬F¾Â¦h¦~ªº«e­º¬Û°¨«¢¸¦º¸¡]¹Ï¡^³Q½Â±b¡A°Æ­º... ¸Ô±¡
¡i©ú³ø±M°T¡j«Xù´µÁ`²Îµo¨¥¤H¨Ø´µ¬ì¤ÒÃÒ¹ê¡A¥h¦~´¿¦¬¨ì¯S®Ô´¶«ß®vªº¹q¶l¡A­n¨D¥L¤ä«ù¯S®Ô´¶¶°¹Î¦b²ö´µ¬ì¿³«Ø¼¯¤Ñ¤j¼Ó¡C ¨Ø´µ¬ì¤Ò«ü¦b¥h¦~¬ü°ê... ¸Ô±¡
¬ü°ê°ê®a®Ö¦w¥þ§½¡]NNSA¡^©P¤@¡]28¤é¡^¤½¥¬¡A¥»¤ë8¤é¦b¤ºµØ¹F¦{Áp¦PªÅ­x²Ä¤G«×§¹¦¨B61-12®Ö¼u­¸¦æ´ú¸Õ¡A½T»{®Ö¼uªº«D®Ö¤l¥\¯à»P¾Ô¾÷ªº·f... ¸Ô±¡

©ú³øºô¯¸ ¡P ª©Åv©Ò¦³ ¡P ¤£±oÂà¸ü
Copyright © 2017 mingpaocanada.com All rights reserved.
Ming Pao Daily News A wholly owned subsidiary of Ming Pao Enterprise Corporation Ltd.
Toronto Chinese Newspaper

1355 Huntingwood Drive, Scarborough, Ontario, Canada M1S 3J1 | Tel.: (416) 321-0088 | Fax: (416) 321-9663 | Advertising Hotline Tel: (416) 673-8250